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Anti-PGHS-1, Monoclonal

Product Overview

OBR carries several monoclonal antibodies that were made against ovine Prostaglandin H Synthase 1 (PGHS-1), also known as Cyclooxygenase 1 (COX-1), and are specific for COX-1 without cross reactivity to Cyclooxygenase 2 (COX-2).


DeWitt, D.L., Day, J.S., Sonnenburg, W.K., and Smith, W.L. Concentrations of PGH Synthase and PGI2 Synthase in the Endothelium and Smooth Muscle of Bovine Aorta. J. Clin. Invest. 72: 1882 (1983). OXFORD BIOMEDICAL RESEARCH

DeWitt, D.L., Rollins, T.E., Day, J.S., Gauger, J.A., and Smith, W.L. Orientation of the Active Site and Antigenic Determinants of Prostaglandin Endoperoxide (PGH) Synthase in the Endoplasmic Reticulum. J. Biol. Chem. 256: 10375 (1981).

Pagels, W.R., Marnett, L.J., DeWitt, D.L., and Smith, W.L. Immunochemical Evidence for the Involvement of Prostaglandin Endoperoxide Synthase in HydroperoxideDependent Oxidations by Ram Seminal Vesicles. J. Biol. Chem. 258: 6517 (1983).

Smith, W.L., and Rollins, T.E. Characteristics of Rabbit Anti-PGH Synthase Antibodies and Use in Immunochemistry. Methods in Enzymology 86: 213 (1982).

DeWitt, D.L., Day, J.S., Gauger, J.A., and Smith, W.L. Monoclonal Antibodies Against PGH Synthase: An Immunoradiometric Assay for Quantitating the Enzyme. Methods in Enzymology 86: 229 (1982).

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