Product Overview
Placental growth factor (PlGF), a member of the vascular endothelial growth factor family, was originally discovered in the placenta, but is also present in a range of other tissues including the heart. PlGF stimulates angiogenesis via binding to the membrane-spanning receptor Flt-1 and exacerbates atherosclerosis by stimulating the migration of monocytes/ macrophages into the arterial wall. PlGF plays an important role in a range of pathological conditions including pre-eclampsia, cardiovascular diseases, and tumor progression. Plasma PlGF levels rise steadily throughout pregnancy from the level of nonpregnant women (< 50 pg/mL) to levels exceeding 500 pg/mL after 30 weeks of gestation. In pre-eclampsia, PlGF levels are far lower than normal pregnancy levels.
References
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Albonici L, Benvenuto M, Focaccetti C, Cifaldi L, Miele MT, Limana F, Manzari V, Bei R. PlGF Immunological Impact during Pregnancy. Int J Mol Sci. 2020 Nov 18;21(22):8714. doi: 10.3390/ijms21228714. PMID: 33218096; PMCID: PMC7698813.
Dewerchin M, Carmeliet P. PlGF: a multitasking cytokine with disease-restricted activity. Cold Spring Harb Perspect Med. 2012 Aug 1;2(8):a011056. doi: 10.1101/cshperspect.a011056. PMID: 22908198; PMCID: PMC3405829.
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