Anti-M1DG MoAB.

This monoclonal antibody was developed against the malonaldehyde-deoxy guanosine adduct, 3-b-erythro-pentofuranosylpyrimido[1,2-a]purin-1093H0-one (abbreviated M1G-R), and extensively characterized.3,5 It is highly specific for M1G-R and has already been used for immunoaffinity isolation of M1G prior to GC/MS. Less than 5 fmol of M1G-R in MDA-modified DNA can be detected by an immunoslot blot assay for the quantitation of MDA-modified DNA using this antibody.