OBR carries several monoclonal antibodies that were made against ovine Prostaglandin H Synthase 1 (PGHS-1), also known as Cyclooxygenase 1 (COX-1), and are specific for COX-1 without cross reactivity to Cyclooxygenase 2 (COX-2).
DeWitt, D.L., et al., Concentrations of PGH Synthase and PGI2 Synthase in the Endothelium and Smooth Muscle of Bovine Aorta. J. Clin. Invest. 72: 1882 (1983).
DeWitt, D.L., et al., Orientation of the Active Site and Antigenic Determinants of Prostaglandin Endoperoxide (PGH) Synthase in the Endoplasmic Reticulum. J. Biol. Chem. 256: 10375 (1981).
Pagels, W.R., et al., Immunochemical Evidence for the Involvement of Prostaglandin Endoperoxide Synthase in Hydroperoxide-Dependent Oxidations by Ram Seminal Vesicles. J. Biol. Chem. 258: 6517 (1983).
Smith, W.L. and Rollins, T.E., Characteristics of Rabbit Anti-PGH Synthase Antibodies and Use in Immunochemistry. Methods in Enzymology 86: 213 (1982).
DeWitt, D.L., et al., Monoclonal Antibodies Against PGH Synthase: An Immunoradiometric Assay for Quantitating the Enzyme. Methods in Enzymology 86: 229 (1982)