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Histone H3, Human Recombinant

Product Overview

Histone H3 is one of the five main histones involved in the structure of chromatin. H3 has a main globular domain and a long N-terminal tail, and is critical to maintaining the structure of the 'beads on a string' structure of nucleosomes. The N-terminus of H3 protrudes from the globular nucleosome core and is susceptible to post-translational modification. In fact, of the five histones, histone H3 is the one that undergoes the most extensive post-transcriptional modifications. The term “Histone H3” does not distinguish between sequence variants or modification state which play a large role in the dynamics and long-term regulation of genes. Histone H3 is an important protein in the emerging field of epigenetics, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.


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